full-time (38 hours per week) for a period of 4 years

In the NWO-supported project ‘Selective sequestering and quantification of proteins bearing a bioorthogonal chemical label’, we aim to answer the question to what extent gene expression is regulated at the level of protein synthesis and degradation. For this purpose, proteins are time-dependent labeled to allow selective purification and quantification. Tools for purification and quantification are to be developed and tested.

Throughout the project, the PhD student will synthesize resins for bioorthogonal sequestration, test these with proteins and proteomes from cells grown under different conditions, and identify and quantify resultant peptide and protein mixtures with advanced protein chemistry and analysis tools, including multidimensional nanoLC and mass spectrometry.

Information
For more information, please contact Prof. C.G. de Koster, phone + 31 (0)20-5255457, e-mail
For more information about SILS: www.science.uva.nl/sils.

Applications
Applications, quoting the job reference number and marked ‘strictly confidential’ (in the upper left-hand corner of the envelope), should include a curriculum vitae and the names of two persons from whom references can be obtained. Applications should be sent to: Personnel Department, attn: Mrs K. Tensen, personnel advisor, Universiteit van Amsterdam, Faculty of Science, Kruislaan 404, 1098 SM Amsterdam, The Netherlands. Applications may also be e-mailed to They too should bear the job reference number and be accompanied by the documents mentioned above. The closing date for applications is 9 January 2006.

Applicants should hold a master’s degree (or equivalent) in chemistry or biochemistry and have either hands-on experience with some or all of the above-mentioned techniques or, more importantly, the desire to actively acquire all the skills required to participate in this challenging, multidisciplinary project.

- Research trainees, non-tenured lecturers, researchers (Scientific expertise: Natural Sciences)

Additional information about the job:
The appointment will be on a temporary basis for a maximum period of four years (one year plus a further three years after a positive evaluation) and should lead to a dissertation.
An educational plan will be drafted, covering such matters as the attendance of courses and national and international meetings. The appointee will also be expected to assist in the teaching of undergraduates. Based on a full-time appointment (38 hours per week), the gross monthly salary will range from € 1,877 in the first year to € 2,407 in the final year, according to the Dutch salary scales for PhD students.

The Universiteit van Amsterdam Faculty of Science

The Faculty of Science of the Universiteit van Amsterdam is one of Europe’s foremost institutions for higher education and research in its area of expertise. It participates in international science networks and collaborates with both universities and industry. The Faculty has approximately 2,000 students and 1,500 employees spread over four departments and ten research institutes. Each institute has its own research programme, a substantial part of which is externally financed by the Netherlands Organization for Scientific Research (NWO), the Dutch government, the EU and various private enterprises.


Swammerdam Institute for Life Sciences

The Swammerdam Institute for Life Sciences (SILS) is the largest institute of the Faculty of Science with approximately 230 employees including researchers, lecturers, 12 full professors, 60 graduate students and 60 post-docs. The Institute performs research in Life Sciences concentrated around four themes: 1) Plants and Health, 2) The Living Cell, 3) Inside and Beyond the Brain, and 4) Life Science Technologies. Institute members give advanced lectures and courses, while the Institute itself stimulates scientific cooperation between participating groups and colleagues from all over the world.

Employment basis: Temporary for specified period
Duration of the contract: for a period of maximum 4 years

 
Or additional information can be obtained through one of the following links.

You can apply for this job before 09-01-2006 by sending your application to:

When applying for this job always mention the vacancynumber AT 05-1074.