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PhD position available - Marie-Curie Research Training Network
Written by Suleman Shahid
Sunday, 12 February 2006
Within the frame work of the Marie-Curie Research Training Network n°019481
'From FLIM to FLIN' coordinated by Prof Ton Visser, Laser Centre Vrije
Universiteit (Amsterdam) in which 9 European laboratories teamed up to study
single-molecule interactions in live cells a PhD position is available in
Paris-France, starting June 1, 2006 for 3 years.
The scientific project
involves the development of ultra-low background fluorescence detection for
intracellular single-molecule FRET detection. We aim at improving the
signal-to-background ratio (SBR) by using (i) non-linear evanescent-field
excitation, (ii) surface-enhanced evanescent-field, (iii) directional emission
detection, (iv) time-gated lock-in detection.
Biological applications
include the imaging of single intracellularly targeted nanocrystals as FRET
donors, of individual Ca2+ signalling microdomains (see Becherer et al. Nature
Neuroscience 6(8):846-53, 2003) and the study of Ca2+ compartmentalisation in
mouse astrocytes.
This topic is investigated in the Molecular and
cellular biophysics of synaptic transmission group in collaboration with
chemists and neurobiologists of the Ecole Normale Supérieure (ENS). Fluorescence
lifetime and non-linear TIRF experiments will involve a strong interaction with
the Kemnitz group (Berlin, http://www.euro-flin.de/html/img_0353b.html)
We
are looking for a highly motivated candidate with background in physics, applied
physics, microscopic imaging, fluorescence spectroscopy or near-field
techniques. Additional expertise in biophysics, cell biology or molecular
biology will be of advantage.
Candidates should send until April 1, 2006
a letter of motivation, c.v. and publication list, as well as three academic
references. The Oheim lab is actively working towards increasing the percentage
of women in science.
The PhD student will be paid a salary and allowance
based on EU regulations relating to the Marie-Curie training
programme.
