The PhD student will be investigating alarmins (S100A8/9) and Wnt proteins, derived from activated macrophages which recently have been shown to be important in regulating cartilage and bone destruction during rheumatic diseases. The work will be mainly carried out in Nijmegen (PhD student) or in Munster and includes travelling between Nijmegen and Munster.
Tests the effects of the proteins in animal models of rheumatic diseases
Investigates the effects of these proteins in in vitro cartilage and bone destruction assays, thereby using moleculair biology and biochemical techniques.

University Graduate
MSc (or equivalent) in biology or chemistry
Strong motivation tot succeed in scientific research
Well developed social skills directed to work in a team
Experience and interest in immunology and animal Models (art. 9) is relevant
Independent and well-structured

University Medical Centre Nijmegen Reumatology Research Laboratorium

The group of Rheumatology Research and Advanced Therapeutics in Nijmegen has gained a worldwide reputation in basic and clinical rheumatology research. The department takes part in the research program of the Nijmegen Center for Molecular Life Sciences (NCML; http://www. ncmls.kun.nl). The institute trains students an PhD-students and conducts research in medical research. The project will be in close cooperation with the department of Immunology in Munster (Germany) and is financed by the Dutch Arthritis Foundation. In this project we aim to get insight in the mechanism of cartilage/bone destruction by macrophage derived proteins and to develop drug targets which can be used for treatment of rheumatic diseases.

Employment basis: Temporary for specified period
Duration of the contract: 3 years
Maximum hours per week: 36

Additional conditions of employment:
Salary level 10A: maximal € 2572 gross per month

Additional information about the vacancy can be obtained from:

Mr. Dr. P.L.E.M. van Lent, Researcher
Telephone number: +31 24 361 05 12

Mr. Dr .A. Blom, Researcher
Telephone number: +31 24 361 66 19

 
Or additional information can be obtained through one of the following links.

You can apply for this job before 18-08-2008 by sending your application to:

When applying for this job always mention the vacancy number AT 08837.