Ph.D. Student, Faculty of Mathematics and Natural Sciences, Division of Pharmaco

Job description
TOP Institute Pharma (TI Pharma) has granted our proposal to set up a mechanism-based PK-PD modelllng platform. This platform focuses on the transfer of knowledge from academia to the pharmaceutical industry and is a collaborative effort of four academic partners and six industrial partners. Unique to this platform is the availability of shared databases on disease and drug related parameters.

The aim of the platform is to provide a scientific basis for rational drug discovery and development with a strong focus on priority medicines. Challenges are 1) to develop mechanism-based PKPD models to characterise disease progression and to predict the effects of ageing on clinical response and 2) to create a translational research framework that allows extrapolation of preclinical to clinical and epidemiological findings. Existing (pre-) clinical data will be analysed with advanced data analysis software tools such as NONMEM and R.

The disease progression working group will consist of two PhD students and two post-doctoral research fellows. At present, we are looking for a highly motivated PhD student to investigate disease models in COPD. This appointment will be for 4 years.

University Graduate
The PhD student should have the following background and competencies:

Master degree preferably in Biostatistics, Bioengineering, Mathematics, or Theoretical Biology;

Preferably a working knowledge of hierarchical models and the biomedical sciences;

Profound interest in Modelling and Simulation methodology;

Ambitious;

Creative;

Interested to perform research in a unique multidisciplinary setting

Leiden University Faculty of Mathematics and Natural Sciences

Employment basis: Temporary for specified period
Duration of the contract: 4 years
Maximum hours per week: 38

 
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You can apply for this job before 26-08-2008 by sending your application to:

When applying for this job always mention the vacancy number 8-167.