Netherlands: PhD student in regulation of metabolic programming by the intestinal microbiota
The UMCG has a preventive Hepatitis B policy. You may be required to build up sufficient protection against Hepatitis B before you can be appointed. Vaccination is provided by the UMCG if necessary.
Conditions of employment
– A salary of € 2.178,- gross per month in the first year up to a maximum of € 2.790,- gross per month in the last year (scale PhD).
– The conditions of employment comply with the Collective Labour Agreement for Medical Centres (CAO-UMC).
University Medical Center Groningen (UMCG)
Department of Pediatrics
Recent data indicated that changes in the early nutritional environment impact the development of chronic disease (obesity, diabetes, atherosclerotic cardiovascular disease) at adult age. Epigenetic mechanisms like DNA methylation or histone modifications have been proposed to be involved in this metabolic programming. Most of the cells and over 99% of the genes in our body belong to the population of intestinal bacteria, the microbiota that most components of our diet will encounter first. Thereby, an enormous pool of diverse metabolites with biological functions is provided by the microbiota that conceivably have an impact on the interaction between host and environment at all stages of our lives.
The current project (funded by STW) focuses on the interplay between diet and microbiota in the determination of disease risk. Specifically, the mechanisms are explored by which metabolites of the microbiota during early life influence the risk to develop chronic disease in the context of the metabolic syndrome (dyslipidemia, obesity, diabetes, fatty liver/NASH, atherosclerotic cardiovascular disease). Animal models for metabolic programming will be developed and phenotypically characterized, underlying molecular mechanisms are determined by studying epigenetic changes of DNA methylation and histone modification patterns.