Netherland: PhD Student Bioinformatics / Genomic Data Integration at Radboud university medical center

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Job description

Project: Bioinformatics and genomic data integration in urinary bladder cancer: crossing borders.

Urinary bladder cancer (UBC) is the ninth most common tumor worldwide. Our research group aims to contribute to improved treatment and prognosis for UBC patients via elucidation of its genetic background. Improved genotyping technologies have allowed for an in-depth interrogation of variation in the germline and tumor genome in large study populations. Also, efforts like The Cancer Genome Atlas (TCGA) project have led to a tremendous wealth of data on somatic mutations and gene expression in bladder tumor tissue. One of the biggest challenges in genetic research nowadays is to use and integrate all these data. In this project, we aim to optimally exploit and integrate germline genomic data from Dutch and Icelandic UBC populations and data on gene expression and somatic mutations in the quest for (rare) germline variants, genes and pathways for bladder cancer.

The PhD student on this project will be responsible for an integrative analysis of germline genomic and other -omic data in bladder cancer. He or she will evaluate existing data integration techniques and tailor these for application to the UBC data at hand. The results will be disseminated via presentations and articles in peer-reviewed journals.

Research setting: This project is part of the research line from the Cancer Epidemiology group at the Department for Health Evidence. The PhD student will however be part of and supervised by multiple (international) research groups with different expertise. Of the total project duration of 4 years, the PhD student will spend one year at the Division of Oncology, deCODE Genetics, Reykjavik, Iceland. In addition, the student will be placed in the Bioinformatics and Statistics group, Division of Molecular Carcinogenesis, Netherlands Cancer Institute, Amsterdam, and the Centre for Molecular and Biomolecular Informatics, Radboudumc. Also, strong ties will exist with the Department of Human Genetics, Radboudumc.

Requirements

We are looking for a PhD student with a background in computer science / bioinformatics. Highly desirable are interest in and knowledge of molecular biology, statistics, and programming skills. He or she should be highly motivated to work in a multidisciplinary setting at several top research groups in Europe, and eager to learn and disseminate new techniques.

Conditions of employment

  • 36 hours per week
  • Scale 10A: max € 38600 gross per year at full employment (incl. vacation bonus and end of year payments)

Contract type: Temporary, temporary for 4 years

Department

 

Radboud university medical center is a leading academic center for patient care, education and research, with the mission ‘to have a significant impact on healthcare’. Our activities help to improve healthcare and consequently the health of individuals and of society. We believe we can achieve that by providing exceptional quality and personalized care, and by working together in sustainable networks.

Additional information

Applicants should send a letter of intent outlining special interest in the position, overall related qualification, experience and career goals, and a curriculum vitae.

More information about this vacancy can be obtained from Dr. Sita Vermeulen, Department for Health Evidence & Human Genetics, Radboud university medical center, +31 24 361 31 27 orSita.Vermeulen@radboudumc.nl.

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