Netherlands: Postdoc position in Immunology & Rheumatology at AMR

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Job description

Project description B cells and T cells encode antigen specificity in the adaptive immune responses characterizing many immune mediated inflammatory diseases like rheumatoid arthritis (RA). Furthermore these cells also steer anti-drug immunological responses, e.g. against therapeutic macromolecules like anti-TNFα. However, in most responses only few cells actually encode specificity for a particular antigen. To identify and characterize these cells we developed a unique and powerful high-throughput sequencing (HTS) technology which fingerprints individual B- and T-cell receptors and clones. Results of these studies have been published in high impact journals.

Together with a PhD student the postdoc will apply the existing proven technology in the EU sponsored translational project ABIRISK to gain more insight in the development of immunological responses against biological therapeutics, e.g. in multiple sclerosis, inflammatory bowel disease and rheumatoid arthritis. Together with the team the postdoc will refine this molecular technology to identify drug specific cells in vitro, link receptor chain information and develop relevant B- and T-cell receptor constructs.

The postdoc will be embedded in an international research team of approximately 12 people. The individual – in close collaboration with the principal investigator (Dr N de Vries) and team members – will be responsible for project planning, design of experiments, analysis and reporting. Furthermore the candidate will be involved in training and coaching of junior staff.

Requirements

Requirements

• We are looking for enthusiastic and ambitious candidate with a Master degree in Cell Biology, Molecular Life Sciences, Biomedical Sciences, Biochemistry or Medicine, or a related field.

• A strong background in molecular biology and cellular biology is required.

• An interest and/or basic knowledge in cellular immunology will be an advantage.

• The candidate will work in a multidisciplinary international consortium of clinicians and biologists.

Conditions of employment

We offer a POSTDOC position for 36 hours per week for 1 year that can be prolonged to 3 years. The maximum gross full-time monthly salary for this position, depending on qualifications and experience, is € 4001,- (scale 10) in accordance with CAO-UMC. The applicant will get a contract at AMC Medical Research BV, which includes a payment of holiday allowance of 8% and a year-end bonus of 8.3% of the gross annual salary.

If you wish to apply for this position, please use the button ‘Apply’. For questions about this vacancy, please contact: Dr. N de Vries, tel: 020-5665996. We are looking forward to receive your application.

Contract type: Temporary,

Organisation

AMR

The AMC is more than just a hospital. It is a world in which patient care, research and education are integrated, and in which people are always central. It is an academic world full of possibilities for talented individuals that are looking for a place where they can excel. Thinking big, daring to dream, cooperating internationally. And never letting yourself be put off by ‘It’s not possible’ or ‘It won’t work anyway’. That is the AMC mentality.

AMC Medical Research supports financiers, project leaders and coworkers on clear, effective and Legal execution of medical research within the Academic Medical Center (AMC) third parties financed. It contains advising and guidance on project preparations, project services and staffing management.

The department of Clinical Immunology and Rheumatology (chair: Prof. J.W.J. Bijlsma) of the Academic Medical Center/University of Amsterdam is focusing on translational research in inflammatory arthritis, using a combination of clinical trials, human samples, in vitro assays and animal studies. The immunology research of the department is hosted in the laboratory of Experimental Immunology (Prof. T. Geijtenbeek) while genomic research is located in the laboratory for Genome Analysis (Prof. F. Baas). Within the department the team of Dr. N. de Vries focuses on the identification, and immunological and genomic characterization of B and T lymphocytes in autoimmune responses. This research is funded by CTMM (TRACER) and the EU (BeTheCure and ABIRISK) and is performed in close collaboration with Prof F. Baas (Laboratory of Neurogenetics), Prof D.L.P. Baeten (Clinical Immunology & Rheumatology) and Prof A.H.C. van Kampen (Bioinformatics). The team has strong productive (inter)national collaborations

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