Netherlands: PhD Student Clinical Immunology & Genomics at AMR

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Job description

B cells and T cells encode antigen specificity in the adaptive immune responses characterizing many immune mediated diseases like rheumatoid arthritis (RA). Furthermore these cells also steer anti-drug immunological responses, e.g. against therapeutic macromolecules like anti-TNFα. However, in most responses only few cells actually encode specificity for a particular antigen. To identify and characterize these cells we developed a high-throughput sequencing technology which fingerprints individual B- and T-cell receptors and clones. In this EU sponsored project ABIRISK, the PhD student will use this technology to identify and characterize lymphocyte responses in patients with different diseases treated with biological therapies, e.g. in multiple sclerosis, inflammatory bowel disease and rheumatoid arthritis. To this end results from in vitro drug responses and in vivo receptor sequencing will be compared to identify responding B and T cells. These cells will be characterized using a reverse phenotyping and genomic approach. The goal is to gain more insight in the development of these antidrug responses, and to identify early predictors for side effects and response to biologicals. The PhD student will be embedded in an international research team of approximately 12 people, and will be supervised by Dr N de Vries.

Requirements

We are looking for an enthusiastic and ambitious candidate with a Master degree in Medicine, Cell Biology, Molecular Life Sciences, Biomedical Sciences, Biochemistry, or a related field.

• An interest and/or basic knowledge in molecular biology, cellular biology and cellular immunology will be an advantage.

• The candidate will work in a multidisciplinary international consortium of clinicians and biologists.

Conditions of employment

We offer a PhD Student position for 36 hours per week for 1 year that can be prolonged to 4 years. The salary is in accordance with CAO-UMC. Starting with 2162,- in the first year to 2770,- in the fourth year. The applicant will get a contract at AMC Medical Research BV, which includes a payment of holiday allowance of 8% and a year-end bonus of 8.3% of the gross annual salary.

If you wish to apply for this position, please use the button ‘Apply’. For questions about this vacancy, please contact: Dr. N de Vries, tel: 020-5665996. Applications by email will not be taken in consideration. We are looking forward to receive your application.

Contract type: Temporary,

Organisation

AMR

The AMC is more than just a hospital. It is a world in which patient care, research and education are integrated, and in which people are always central. It is an academic world full of possibilities for talented individuals that are looking for a place where they can excel. Thinking big, daring to dream, cooperating internationally. And never letting yourself be put off by ‘It’s not possible’ or ‘It won’t work anyway’. That is the AMC mentality.

AMC Medical Research supports financiers, project leaders and coworkers on clear, effective and Legal execution of medical research within the Academic Medical Center (AMC) third parties financed. It contains advising and guidance on project preparations, project services and staffing management.

The department of Clinical Immunology and Rheumatology (chair: Prof. J.W.J. Bijlsma) of the Academic Medical Center/University of Amsterdam is focusing on translational research in inflammatory arthritis, using a combination of clinical trials, human samples, and in vitro assays. The immunology research of the department is hosted in the laboratory of Experimental Immunology (Prof. T. Geijtenbeek) while genomic research is located in the laboratory for Genome Analysis (Prof. F. Baas). Within the department the team of Dr. N. de Vries focuses on the identification, and immunological and genomic characterization of B and T lymphocytes in autoimmune responses. This research is funded by CTMM (TRACER) and the EU (BeTheCure and ABIRISK) and is performed in close collaboration with Prof F. Baas (Laboratory of Neurogenetics), Prof D.L.P. Baeten (Clinical Immunology & Rheumatology) and Prof A.H.C. van Kampen (Bioinformatics). The team has strong, productive (inter)national collaborations with publications in high impact journals.

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