Netherlands: PhD Position in Department of Hematology at Erasmus MC

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Job description

Severe congenital neutropenia (SCN) is a pediatric bone marrow failure syndrome with a high risk of leukemia development. Leukemia arising in these patients is usually resistant to currently available therapies. The mechanisms underlying the transformation from SCN towards leukemia are unknown.

This project aims to identify the sequential genetic, epigenetic and cellular defects involved in the leukemic transformation of SCN. Special focus will be on identification of early acquired defects, because we think that these early defects have a major impact on the therapy resistant nature of the leukemia. The project involves investigations in patient samples, bone marrow failure mouse models and induced pluripotent stem cells (iPS). Methods that are used include next generation sequencing (whole exome sequencing, RNA-seq, Chip-seq), flow cytometry, cell culture and confocal microscopy.

Requirements

You are a highly-motivated PhD student trained in cell and molecular biology. Students with a medical background and a Research Master degree in molecular medicine are also strongly encouraged to apply.

Conditions of employment

We offer a full-time employment for a period of 4 years. The gross monthly salary will be € 2.141,- per month in the first year, and will grow to € 2.743,-
per month in the fourth year (scale OIO). The conditions of employment are in accordance with the Collective Agreement for Dutch University Medical Centers (CAO UMC).

Contract type: Temporary, 4 years

Organisation

Erasmus MC

Erasmus MC inspires and is challenging. You create your own opportunities in this University Medical Center. Whether it concerns learning and work or work and learning/continued learning. Each and every day our enthusiastic staff devote themselves to excellent, dedicated patient care, pioneering medical research and valued education. A conscious choice for work that matters, both nationally and internationally, at the heart of our multicultural home base ofRotterdam. Where attention to individual staff member comes naturally. Working from the heart. Together with people, for people: ‘patient-centered care’!

Department

Hematology

The Department of Hematology runs an ambitious and internationally recognized research program in the field of hematological malignancies, in particular pre-leukemic syndromes and acute myeloid leukemia. It accommodates a state of the art infrastructure for cell biological, genomic and clinically applied research.

Additional information

For information regarding the scientific content of this project, please contact Professor Ivo P. Touw, PhD, e-mail: i.touw@erasmusmc.nl. For additional
information please contact Mrs. Y. Kirkpatrick, administrative assistant HR, phonenumber (+31 10) 704 4443 or via e-mail: sollicitatie.danieldenhoed@erasmusmc.nl.

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