Netherlands: Scientific Researcher in Human Genetics / Clinical Genetics at Leiden University Medical Center

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Job description

As a scientific researcher you will be part of the larger Neuromics research project, which is funded by the European Commission. In short the Neuromics project studies rare neurodegenerative and neuromuscular diseases with the aims to find novel disease-causing genes, improve diagnostics and develop novel therapies for these disorder
s.Your project will be aimed at further development of antisense oligonucleotide (AON)-based therapy for neuromuscular disorders. The aim is to develop a supporting AON therapy targeting TGF-β and myostatin protein signaling cascades, which have been implicated in the pathology of neuromuscular disorders.
Your task will include working with mouse models for neuromuscular disorders to study the therapeutic potential of the AON-based therapy and to further elucidate the role of TGF-β/myostatin signaling cascades in neuromuscular disorder pathology using primary cell cultures.

You will supervise a PhD student and technician working towards similar goals.

Requirements

You hold an MSc and a PhD degree in biomedical sciences or comparable background. Preferably you have at least 3 year postdoctoral experience with bio-molecular work and have high affinity with translational research. Additionally, you have ample experience in working with experimental mouse models (article 9 certificate required) and cell culture.
This position requires a dedicated, enthusiastic, motivated and flexible team player with excellent communicative skills in English. Working in this promising research team will give you an excellent opportunity to develop your own research line.

Conditions of employment

You will be employed on the basis of a 36-hour week. Appointment is for two years, with a possibility for extension by another 2 years. Your salary will depend on your qualifications and experience, with a maximum of € 4.001– gross per month (scale 10, Collective Labour Agreement for University Hospitals).
The terms of employment offered by the LUMC are highly favourable. For example, you will receive an 8% holiday remuneration, a year-end bonus, a pension arrangement with the National Civil Pension Fund, and, if applicable, a bonus for unsocial hours.
Also, as employee of one of the University Hospitals in the Netherlands, you may join our collective health insurance policy. Moreover, the LUMC offers excellent facilities in the area of education, child-care centres, and career advice. In addition, you may enjoy various leave arrangements and other extras. You can read more about these facilities elsewhere on this site.

Contract type: Temporary, appointment is for two years, with a possibility for extension by another 2 years.

Organisation

Leiden University Medical Center

At the Leiden University Medical Centre (LUMC), we are continually seeking to improve the quality of healthcare. The LUMC aims for excellence in patient care, research, teaching, training and continuing education.

Department

Department of Human Genetics.

You will work within LUMC’s Department of Human Genetics and collaborate with the department of Molecular Cell Biology. State of the art technical equipment for gene expression analysis and protein analysis is available at our department and at the Leiden Genome Technology Center (LGTC). Mouse models of DMD are available at LUMC’s animal facility (PDC). You will work in a team of 4 postdocs, 4 PhD students and 6 technicians that is lead by an associate professor. Within this group you will supervise 1 PhD student and 1 technician.

Additional information

A detailed job description can be found at www.lumc.nl/vacancies

If you have any questions, or if you want more information about this position, please contact Dr Annemieke Aartsma-Rus, e-mail: A.M.Aartsma-Rus@lumc.nl or telephone +31 71 526 9436 or Dr Willem Hoogaars, e-mail :W.M.H.Hoogaars@lumc.nl or telephone +31 71 5269420

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