Netherlands: PhD position Transcranial Magnetic Stimulation in Epilepsy at University of Twente (UT)

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Job description:

Epilepsy is a dynamic neurological disease, with a prevalence of ~1%, characterized by the occurrence of seizures, resulting from an abnormal balance in excitatory and inhibitory circuits.   Key challenges in epilepsy include reliable and efficient diagnostics and the evaluation of treatment effects. As the routine EEG has a limited sensitivity, there is a need for improved diagnostic measures. Cortical excitability can be studied with Transcranial Magnetic Stimulation (TMS) and TMS/EEG. In our research department, we use robot-guided navigated TMS combined with 64-channel EEG.   The main emphasis of the current project is to implement double-pulse TMS, combined with high-density scalp EEG, to further study changes in cortical excitability in patients with epilepsy, including the evaluation of treatment effects. You will perform TMS/EEG measurements in healthy subjects and patients with epilepsy. In the start-up period, you will closely cooperate with the current PhD student in this project.   There is a cooperation with the department of neurology and clinical neurophysiology of the Medisch Spectrum Twente, a large community hospital near the University.   This project is financially supported by TWIN: Stichting Toegepast Wetenschappelijk Instituut voor Neuromodulatie.


You have a Master degree in Technical Medicine, Biomedical Engineering or Applied Physics and a strong interest in biomedical signal processing and clinical neuroscience. You are well trained in (biomedical) signal analysis and have good programming skills (Matlab). Good communication and organizational skills are essential. Prior experience with patient research and EEG measurements is an advantage.   For further information (not for sending in applications) please contact: Prof. dr. ir. Michel J.A.M. van Putten, Department of Clinical Neurophysiology. E-mail: m.j.a.m.vanputten(at) Phone: +31 53 489 4757 (Tuesday afternoon and Wednesday).

Conditions of employment:

The research will be carried out in the Clinical Neurophysiology group of Prof. Michel van Putten at the University of Twente and Medisch Spectrum Twente, Enschede, the Netherlands. The group is embedded in the MIRA Institute of Biomedical technology and Technical medicine. We offer a stimulating scientific environment and an excellent research infrastructure. For each project, we offer a contract for a full position (1 FTE, 38 working hours per week) for four years. Your monthly salary develops from€ 2083 gross in the first year to € 2664 gross in the last year. Furthermore, we offer a holiday allowance of 8%, an end-of-year bonus of 8.3% and a number of additional benefits. The University of Twente provides excellent campus facilities, and actively supports professional and personal development.


The University of Twente. We stand for life sciences and technology. High tech and human touch. Education and research that matter. New technology which drives change, innovation and progress in society. The University of Twente is the only campus university in the Netherlands; divided over six faculties we provide more than fifty educational programmes. The University of Twente has a strong focus on personal development and talented researchers are given scope for carrying out pioneering research.

Within the TNW Faculty (Faculty of Science & Technology) of the University of Twente some 700 staff members and more than 1100 students are involved in training and research on the interface of chemical technology, applied physics and biomedical technology. Fields of application include sustainable energy, process technology and materials science, nanotechnology and technical medicine. Research, which enjoys a high profile both at home and internationally, has been accommodated in the multidisciplinary research institutes IMPACT, MESA+ and MIRA. The faculty works together intensively with industrial partners and researchers in the Netherlands and abroad and conducts extensive research for external commissioning parties and funders.

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