Netherlands: PhD student in Mitochondrial Neurobiochemistry at Radboud University Nijmegen Medical Centre (RUN MC)

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Job description

The Mitochondrial Neurobiochemistry Group of the Nijmegen Centre of Mitochondrial Disorders (NCMD) and the Department of Biochemistry investigates the role of mitochondria in the development of neurodegenerative diseases. We aim at identifying and understanding the underlying molecular and signaling mechanisms. The research spectrum includes the identification and characterization of new proteins involved in mitochondrial diseases as well as the qualitative and quantitative analyses of expression and function of known proteins, of mitochondrial and cellular functions and signaling pathways in the central nervous system. The methods applied for these studies include molecular biological and cell culture techniques and methods of protein chemistry and fluorescence live cell imaging.

We are expanding our investigations from in vitro to in vivo studies mainly using rodents as a model system.
The newly established Mitochondrial Neurobiochemistry Group is fully integrated into the NCMD in which more than 60 dedicated people work in the field of mitochondrial medicine addressing challenging questions reaching from basic to applied research including clinical applications.

Tasks:

  • Designing and performing scientific research in the area of mitochondrial biology and neuroscience in health and disease
  • Generating and analyzing data in order to contribute to scientific publications and presenting results at scientific meetings
  • Working in an international team and stimulating environment
  • Completing the research project with a scientific dissertation

Requirements

  • Master or Diploma degree in Biochemistry, Biology, Biomedical Sciences or comparable degree
  • Strong interest in mitochondrial and neuroscientific research at the frontiers of science
  • Enthusiastic and highly motivated individual with a flexible work attitude and a well-structured work style
  • Skills and experience in protein biochemistry and molecular/cellular biology
  • Permitted to work with animals is advantageous
  • Fluency in spoken and written English
  • Open-minded for new approaches and plenty of team spirit

Conditions of employment

  • Temporary, 3 years
  • 36 hour per week
  • Scale 10A: max € 38600 gross per year at full employment (incl. vacation bonus and end of year payments)

Organisation

Radboud University Nijmegen Medical Centre (RUN MC)

Department

Combining research in the fields of mitochondrial and neurodegenerative diseases the Mitochondrial Neurobiochemistry Group is fully integrated into the Nijmegen Centre for Mitochondrial Disorders (NCMD) which represents an international reference centre for clinical care, diagnostics and research of patients suspected for or with established disturbances of the mitochondrial energy metabolism. The NCMD integrates all mitochondrial medicine clinical, diagnostic and research activities of the Radboud University Nijmegen Medical Cenbtre (RUNMC) and Radboud University. The NCMD staff members have extensive working relationships with mitochondrial centres across the world. The NCMD research mission is to understand molecular and cellular bioenergetics in health and disease in order to make substantial contributions in developing a cure for mitochondrial disease. As such a from-molecule-to-human and from physiology-to pathology-to therapy strategy has been adopted.

The research at the NCMD and the Department of Biochemistry serve as a basis for academic teaching and training of Master and PhD students. Both institutions are part of a leading multidisciplinary graduate school studying and teaching molecular mechanisms of disease in the fields of molecular biomedicine, biology and translational research.

Additional information

Additional information about the vacancy can be obtained from Dr. Susanne Arnold, Associate Professor for Biochemistry, NCMD & NCMLS, S.Arnold@ncmls.ru.nl(Use this E-Mail address only for information, for application use the apply button.)

Detailed information about the NCMD can also be found at www.ncmd.nl.

Applicants should include a letter of intent outlining special interest in the position, overall related qualifications, experience and career goals, a curriculum vitae with copies of graduation certificates and letters of recommendation and/or names and addresses of professional references.

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