Netherlands: PhD Candidate in Chemometrics for Flow Cytometry at Radboud University

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Description:

As a PhD student you will perform innovative research in the quantitative analysis of medical flow cytometry data collected in a hospital environment. You will try to obtain more information of higher quality for early and personalized disease diagnosis and elucidating comprehensive disease mechanisms. You will use existing chemometrics data analysis methods (principal component analysis, partial least squares regression), but you will also develop and extend novel data analysis methods that better fit the specific structure of flow cytometry data, using data from state-of-the-art flow cytometric/fluorescence assisted cell sorting technology on a large variety of medical conditions. You will primarily focus on data analysis, but will also be able to obtain considerable hands-on experience with the available flow cytometry technology, integrating it with ongoing research. You will communicate your findings through papers in peer-reviewed research journals and via oral presentations at international scientific symposia. You will also be involved in the teaching of BSc and MSc courses offered by the Laboratory for Analytical Chemistry and in the supervision of student internships.

Requirements:

– you have a university degree (MSc) in analytical chemistry (preferably chemometrics), bioinformatics or a related field that involves quantitative data analysis;
– you have demonstrable experience with multivariate data analysis methods (e.g. principal component analysis, partial least squares regression);
– you have experience with MATLAB, or with a an alternative programming environment and are willing to learn MATLAB;
– you thrive in an interdisciplinary research field, and can bridge quantitative data analysis with biomedical research;
– you have an excellent command of English and are able to use this language in a scientific context;
– experience with Flow Cytometry technology is a plus, but not essential.

Conditions of employment:

– you will be appointed for a period of four years. Your performance will be evaluated after 18 months. If the evaluation is positive, the contract will be extended by 2.5 years;
– you will be classified as a PhD Candidate (promovendus) in the Dutch university job-ranking system (UFO).
– the gross starting salary amounts to €2,062 per month based on full-time employment, and will increase to €2,638 in the fourth year;

Contract type: Temporary, 4 years

Organisation:

Radboud University Nijmegen

Strategically located in Europe, Radboud University Nijmegen is one of the leading academic communities in the Netherlands. A place with a personal touch, where top-flight education and research take place on a beautiful green campus in modern buildings with state-of-art facilities.

Department:

Faculty of Science

The department of Analytical Chemistry/Chemometrics group (Prof. L.M.C. Buydens) has a 40-year history on the forefront of chemometrics research, and is part of the Institute for Molecules and Materials (IMM), the largest research institute of the Faculty of Science at Radboud University Nijmegen. The research of the department of Analytical Chemistry/Chemometrics is focused on the development, optimisation and validation of chemometrical methodologies and strategies for all aspects of data exploration, modelling and interpretation of multivariate and megavariate chemical, biological and medical data and images. The aim of the department is to perform methodological research that is valuable across different application areas, together with application-oriented research in which these methods are applied and validated for pioneering science in chemistry, biology and medicine. The research programme is designed around three areas: (1) Development of novel explorative (visualisation) and quantitative techniques. Introduction of prior knowledge and strategies for data fusion, (2) Spectroscopic (image) analysis and (3) Molecular profiling (i.e. genomics, proteomics and metabolomics). The department is responsible for several Bachelor’s and Master’s degree courses in the molecular sciences and molecular life sciences curricula of the Faculty of Sciences. The courses cover chemical analysis, basic statistics and both basic and advanced chemometric data analysis. The department currently consists of five staff members, two post-doctoral researchers and nine PhD students. The group has strong international ties with academia and industry, which have led to many strong research collaborations. This project will be conducted together with the Flow Cytometry lab at the department of Respiratory Medicine of the University Medical Centre Utrecht, headed by Prof. Leo Koenderman.No commercial propositions please.

Additional information:

Dr Jeroen Jansen, Assistant Professor
+31 24 3652512
jj.jansen@science.ru.nl
Prof. Lutgarde Buydens, Group Leader
+31 24 3653192
l.buydens@science.ru.nl
www.ru.nl/science/analyticalchemistry/
Radboud University Nijmegen
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