Amsterdam:PhD Position Methodology of Clinical Trials in Small Populations at AMC

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Job description:

The ASTERIX (Advances in Small Trials dEsign for Regulatory Innovation and eXcellence) consortium is an international consortium funded by the EU (FP7). Its aim is to provide a systematized, patient inclusive, approach to decision making on benefit risk for new drugs for rare diseases – based on improved and validated methodology for clinical trials in small populations – ensuring cost effective clinical trials deriving reliable results for small populations. Two key areas of improvement that will be explored are explicit use of information and data from patient registries and explicit elicitation of patient preferences for treatment outcomes as well as other design features. The main activities of the PhD student will include performing systematic reviews of the literature, and the design, conduct and reporting of quantitative and qualitative approaches to elicit information from patient representatives. All work will be prepared with the AMC team and in close communication with the other European partners in the Asterix consortium.


We are looking for a highly motivated candidate with a (nearly) completed research masters degree in health science, medical biology, epidemiology or an equivalent direction. The candidate should have a strong methodological background and high affinity with patient involvement in clinical research. Excellent proficiency of the English language, well-developed social skills and a well-structured and transparent working style are essential, as well as the ability to work with statistical and bibliographical programs such as SPSS and Reference Manager. Preferably, experience has been gathered as an active researcher in all phases of qualitative as well as quantitative empirical research, including systematic reviews.

Conditions of employment:

A challenging project to work on within an inspiring international consortium, as member of an ambitious, dedicated and coherent team. Gross compensation will be according to standard salary levels for PhD students starting with a salary of € 2141,- with a yearly growth to € 2743,- gross a month. You will be employed by AMC Medical Research BV. This is a full-time appointment (36 hours per week). The contract will be limited to a total of 4 years and has to be completed with a successful defense of a PhD thesis.

If you want to apply for this position, use the button ‘solliciteren’. For more information about this position please contact Dr Hanneke van der Lee, e-mail:

Applications via this emailadress will not be taken in consideration. If you have any technical problems with our website, please contact the Werkwinkel at 020-5667722.

We are looking forward to meeting you!

Contract type: Temporary,


The AMC is more than just a hospital. It is a world in which patient care, research and education are integrated, and in which people are always central. It is an academic world full of possibilities for talented individuals that are looking for a place where they can excel. Thinking big, daring to dream, cooperating internationally. And never letting yourself be put off by ‘It’s not possible’ or ‘It won’t work anyway’. That is the AMC mentality.AMC Medical Research supports financiers, project leaders and coworkers on clear, effective and Legal execution of medical research within the Academic Medical Center (AMC) third parties financed. It contains advising and guidance on project preparations, project services and staffing a temporary researcher you will be contracted by AMC Medical Research. The related AMC department which you will service is physically your workplace. Working directly with your supervisor and your colleagues within your expertise or institution will be the base for your content job, your daily management and your working environment. The AMC Medical Research BV general employment conditions are largely similar to those of Academic Medical Center.

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