Germany: PhD Scholarship in Biology

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Applications are invited for a PhD scholarship in Biology. This position is embedded in the Manchot Graduate School “Molecules of Infection” (http://www.moi.uni-duesseldorf.de) and is available in the laboratory of Dr. Fleig (Lehrstuhl für funktionelle Genomforschung der Mikroorganismen, Universität Düsseldorf). The aim of the new Graduate School is to implement a unique training for scientific PhD students in the field of infectiology. The projects undertaken by the Manchot Graduate School “Molecules of Infection” (GS MOI) concentrate on molecules that play important roles during infections, and these will be characterized in the context of specific disease models.

The advertised PhD project focuses on understanding the regulation of the dimorphic transition in the fission yeast Schizosaccharomyces japonicus.

The ability to alter the growth form in response to environmental conditions is an important virulence associated trait of pathogenic fungi that is also present in the non-pathogenic fission yeasts S. pombe and S. japonicus. We found that the S. pombe Asp1 protein, which is a member of the conserved Vip1 1/3 inositol polyphosphate kinase family is a key regulator of the morphological switch (http://www.ncbi.nlm.nih.gov/pubmed/20624911). In this project, we will extend our analysis of Vip1 family function to S. japonicus. This fungus is closely related to S. pombe, dimorphic and can change between unicellular and hyphal growth. It is thus a suitable model system to study the molecular requirements needed for the dimorphic switch in pathogenic fungi.

Candidates should hold a diploma, Masters Degree or equivalent in biology, biochemistry or a cognate area. Experience in yeast methods and molecular biology is of advantage. The successful candidate will enroll as of 1.10.2010. The scholarship which will be awarded for 3 years consists of a monthly stipend of 1.345 € plus extras.

Please contact Dr. I. Kruempelbeck (inge.kruempelbeck[ at ]uni-duesseldorf.de) for further information concerning the application process and for requesting the application form. The closing date for receipt of completed applications is 15 September 2010.

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