PhD Studentship in Chemistry

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Development of novel metal-based molecular receptors for bio-imaging of nitric oxide.

Nitric Oxide (NO) plays a very important role as a
messenger molecule in the cardiovascular, nervous and
immune systems. Consequently there is great interest in
finding efficient and reliable means of imaging it "in
action".

This project aims to develop a series of new chemical
receptors for the detection of NO. The project will
involve the synthesis of new metal complexes with the
capability of selectively binding NO. Upon binding it, a
physical response (e.g. optical changes) will be triggered
that can then be measured and hence concentrations of NO
detected. Once a series of probes have been synthesised and
their sensing properties studied, their role in a
biochemical context will be studied. In particular, the
probes will be functionalised so that they can be anchored
in the cell’s membrane and consequently can be used to
image the traffic of this small messenger molecule in the
boundaries of the membrane.

Candidates (who should be UK or EU citizens due to
restrictions imposed by the funding body) should have, or
expect to receive, a chemistry degree (at least II.1 or
equivalent) and have an interest in coordination and
supramolecular chemistry with applications to biological
problems.

This project is part of a collaboration between Dr. Ramon
Vilar (Chemistry Department), Dr. Nick Long (Chemistry
Department) and Dr. R. Woscholski (Department of Biological
Sciences) as part of the Chemical Biology Centre at
Imperial College London.

The studentship is available from October 2006 for four
years. The studentship will cover the fees and stipend (ca.
£14,000 per/annum) for 4 years.

Further details and application procedures can be obtained
from Dr. Ramon Vilar (
r.vilar@imperial.ac.uk
).

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