Netherlands: PhD Candidate Biomedical Engeneering

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The department of Biomedical Engineering
comprises 40 researchers and focuses on the development of technology
for cardiovascular diagnosis and therapy. The Biomechanics Laboratory

nl/ThoraxcenterBME/bml/) is part of Biomedical Engineering and its
research mainly focuses on the influence of biomechanical parameters on
the development and progression of atherosclerosis.

Rupture of atherosclerotic plaques in large arteries is responsible for life threatening cardiovascular events,

including myocardial infarction and stroke. In this project, vulnerable plaques in the carotid arteries of genetically

modified mice will be studied. In vitro imaging experiments will be
carried out to measure pressure induced deformation and rupture of
plaques by means of high resolution MRI. The in vitro experiments will
be used to

validate a biomechanical finite element model of atherosclerotic
plaques. The validated biomechanical plaque model will be used to study
plaques in mice in vivo. A pharmacological intervention will induce
hypertension, which will lead to plaque rupture and we will investigate
whether the biomechanical model of the plaque can be used to predict
the location of plaque rupture. The PhD candidate will carry out the
imaging studies in collaboration with University of Leiden, and she/he
will apply the finite element model, which will be developed with the


University Graduate
Applicants have a
master’s degree in engineering, preferably in biomedical engineering,
physics, electrical or mechanical engineering, or applied mathematics.
Basic understanding of imaging techniques and affinity with
biomechanics are requirements. Since this project will require
collaboration with many investigators from various

backgrounds, good communicational skills are a prerequisite.


Erasmus MC
Het Erasmus MC is een uiterst veelzijdig
universitair medisch centrum. Waar onderzoek, onderwijs en
patiëntenzorg zijn samengebracht. Waar samenwerking, initiatief en
resultaatgericht werken passen bij de ambities van het Erasmus MC.
Beter worden.

Conditions of employment

Employment basis: Temporary for specified period
Duration of the contract: 4 years
Maximum hours per week: 36

Additional conditions of employment:
Your gross salary is based on our collective labour agreement for
University Medical Centers and starts at € 2.007,- gross per month up
to € 2.572,- gross per month in the fourth year.

Additional Information

Or additional information can be obtained through one of the following links.
For further details on the position, please contact Frank Gijsen, telephonenumber +31 10 704 4039, e-mail

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You can apply for this job before 07-11-2008 by sending your application to:

Erasmus MC
S. Saskia Bender
Postbus 2040
3000 CA Rotterdam
The Netherlands
E-mail address:

Please send your application and CV to Erasmus
MC, attn. Mrs. S. Bender, room Bd 587 Thoraxcenter, P.O. Box 2040, 3000
CA Rotterdam, vacancynumber 37.11.08.C9 on the letter and envelope, or

email to

When applying for this job always mention the vacancy number AT-37.11.08.C9.

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