Netherlands: Postdoc in neurophysiology

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It is now firmly established that
activity-dependent modulation of presynaptic secretion is a central
aspect for real-time information processing in the brain. However, the
intracellular signal transduction cascades responsible for this
modulation are poorly understood. We have recently characterized some
of the genes required for Ca2+- and phospholipase C-dependent
modulation (Wierda et al. 2007, Neuron 54 pp275). This project aims to
identify the cross-talk between these genes and other protein kinase
pathways in the terminal and their regulation by presynaptic receptors
and proposed retrograde signaling.

Description of work

This project uses patch clamp and null mutant rescue approaches in
microdot island cultures (autapses). Several presynaptic genes have
been silenced and viral based rescue construct are available. Some of
the experiments will also combine synaptophysin-pHluorin based imaging
of secretion. Autaptic neurons and viral stocks are in principle
supplied by technicians.

All the patch clamp and optical equipment and analysis software are available from the start of the project.


University Graduate
We are looking for
candidates with a PhD in neuroscience or physiology, extensive
experience with patch clamp and a strong motivation to pursue a career
in science. Some experience with cell culture and life cell imaging are


VU University Amsterdam Faculty of Earth and Life Sciences
Amsterdam, the capital of the Netherlands, has
been a renowned cultural, scientific and commercial centre for many
centuries. It was here, in 1880, that the VU University Amsterdam first
opened its doors to students. VU stands for ‘Vrije Universiteit’, which
means ‘Free University’. Here, ‘free’ refers to freedom of state and
church interference. Vrije Universiteit Amsterdam was established in
1880 by orthodox protestants. Nowadays it aims to be inspiring,
innovative and involved.

Throughout the past century, the university has continued to
expand. It now comprises twelve faculties and has teaching facilities
for 18,000 students.

Click here for an overview of faculties and institutes:

The university campus and university hospital are situated in the
south-western part of Amsterdam, one of the most dynamic and
fast-growing business districts in the Netherlands. The international
airport of Schiphol-Amsterdam is 10 kilometres away, just 8 minutes by
train. With more than fifty undergraduate (or bachelor’s) programmes
and almost a hundred postgraduate (or master’s) programmes, the Vrije
Universiteit Amsterdam offers a wide choice of study options. The
programmes are of a high quality, the atmosphere is very conducive to
study, and the teaching staff is easily accessible.

The Faculty of Earth and Life Sciences is the
result of the merger between the former Faculty of Earth Sciences,
Faculty of Biology and the Institute of Environmental Studies. The
Faculty is offering education and doing research in the fields of:

Earth Sciences (physical geography and geology)


Biomedical Sciences


Public Health

Environmental Studies

Conditions of employment

Employment basis: Temporary for specified period
Duration of the contract: temporary

Additional conditions of employment:
You can find information about our excellent fringe benefits of
employment – including holiday allowances of 8 % per year – at


Gross monthly salaries range from € 2.916,- to € 3.678,- (scale 10) in the last year of appointment depending on experiences.

Additional Information

Or additional information can be obtained through one of the following links.

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You can apply for this job before 30-09-2008 by sending your application to:

VU University Amsterdam
Faculty of Earth and Life Sciences
Els Borghols
De Boelelaan 1085
1081 HV Amsterdam
The Netherlands
E-mail address:

Applications and more info

Please send CV and cover letter to Els Borghols at e-mail: with

‘position PD-33’ in the subject line.

More info can be obtained via website or from Matthijs
Verhage, at e-mail: Applications will be
acknowledged in the first week of September 2008.

Any other correspondence in response to this advertisement will not be dealt with.

When applying for this job always mention the vacancy number 1.2008.00254.

The short URL code for this job opening is: 00353-670.

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