Netherlands: Ph.D. Student, Faculty of Mathematics and Natural Sciences,

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Ph.D. Student, Faculty of Mathematics and Natural Sciences, Division of Pharmaco
Job description

TOP Institute Pharma (TI Pharma) has granted our proposal to set up
a mechanism-based PK-PD modelllng platform. This platform focuses on
the transfer of knowledge from academia to the pharmaceutical industry
and is a collaborative effort of four academic partners and six
industrial partners. Unique to this platform is the availability of
shared databases on disease and drug related parameters.

The aim of the platform is to provide a scientific basis for
rational drug discovery and development with a strong focus on priority
medicines. Challenges are 1) to develop mechanism-based PKPD models to
characterise disease progression and to predict the effects of ageing
on clinical response and 2) to create a translational research
framework that allows extrapolation of preclinical to clinical and
epidemiological findings. Existing (pre-) clinical data will be
analysed with advanced data analysis software tools such as NONMEM and

The disease progression working group will consist of two PhD
students and two post-doctoral research fellows. At present, we are
looking for a highly motivated PhD student to investigate disease
models in COPD. This appointment will be for 4 years.


University Graduate
The PhD student should have the following background and competencies:

Master degree preferably in Biostatistics, Bioengineering, Mathematics, or Theoretical Biology;

Preferably a working knowledge of hierarchical models and the biomedical sciences;

Profound interest in Modelling and Simulation methodology;



Interested to perform research in a unique multidisciplinary setting


Leiden University Faculty of Mathematics and Natural Sciences

Conditions of employment

Employment basis: Temporary for specified period
Duration of the contract: 4 years
Maximum hours per week: 38

Additional Information

Or additional information can be obtained through one of the following links.

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You can apply for this job before 26-08-2008 by sending your application to:

Faculty of Mathematics and Natural Sciences
Einsteinweg 55
Dr. O. Della Pasqua
Postbus 9502
2300 RA Leiden
E-mail address:

When applying for this job always mention the vacancy number 8-167.


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