Netherlands: PhD student biology or chemistry

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The PhD student will be investigating alarmins
(S100A8/9) and Wnt proteins, derived from activated macrophages which
recently have been shown to be important in regulating cartilage and
bone destruction during rheumatic diseases. The work will be mainly
carried out in Nijmegen (PhD student) or in Munster and includes
travelling between Nijmegen and Munster.

Tests the effects of the proteins in animal models of rheumatic diseases

Investigates the effects of these proteins in in vitro cartilage
and bone destruction assays, thereby using moleculair biology and
biochemical techniques.


University Graduate
MSc (or equivalent) in biology or chemistry

Strong motivation tot succeed in scientific research

Well developed social skills directed to work in a team

Experience and interest in immunology and animal Models (art. 9) is relevant

Independent and well-structured


University Medical Centre Nijmegen Reumatology Research Laboratorium

The group of Rheumatology Research and Advanced
Therapeutics in Nijmegen has gained a worldwide reputation in basic and
clinical rheumatology research. The department takes part in the
research program of the Nijmegen Center for Molecular Life Sciences
(NCML; http://www. The institute trains students an
PhD-students and conducts research in medical research. The project
will be in close cooperation with the department of Immunology in
Munster (Germany) and is financed by the Dutch Arthritis Foundation. In
this project we aim to get insight in the mechanism of cartilage/bone
destruction by macrophage derived proteins and to develop drug targets
which can be used for treatment of rheumatic diseases.

Conditions of employment

Employment basis: Temporary for specified period
Duration of the contract: 3 years
Maximum hours per week: 36

Additional conditions of employment:
Salary level 10A: maximal € 2572 gross per month

Additional Information

Additional information about the vacancy can be obtained from:

Mr. Dr. P.L.E.M. van Lent, Researcher
Telephone number: +31 24 361 05 12

Mr. Dr .A. Blom, Researcher
Telephone number: +31 24 361 66 19

Or additional information can be obtained through one of the following links.

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You can apply for this job before 18-08-2008 by sending your application to:

G.J. Rem, HRM counselor
P.O. Box 9101
6500 HB Nijmegen
The Netherlands
E-mail address:

When applying for this job always mention the vacancy number AT 08837.


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