Holland: Postdoc / PhD student Molecular Neurobiology

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The postdoctoral researcher or PhD student will
be working in the field of Molecular Neurobiology (incl.
neurodevelopmental aspects) using in particular molecular,
cell-biological, physiological and behavioural research approaches.
He/she will participate in unravelling the molecular basis of
neurodevelopmental psychiatric disorders, particularly the effects of
(epi)genetic and environmental (early-life stress) factors on brain
development/ behavioural phenotypes. Project in brief: A fundamental
question in the neurobiology of psychiatric disorders is how the
interaction between predisposing genes and a change in environment
(e.g. early-life stressors) can produce a phenotype that is vulnerable
to a neurodevelopmental disorder such as schizophrenia. To tackle this
question, a rat model has been developed that displays a complex
phenotype remarkably similar to that of patients with schizophrenia. We
want to establish the molecular genetic and neurobiological basis of
the rat model. In humans, we try to identify the susceptibility genes
for psychiatric disorders. Central question of the project: what
programs the brain for vulnerability to neurodevelopmental psychiatric
disorders? Through our studies we hope to highlight the crucial role of
neurodevelopmental signalling pathways and stressful (early) life
events in programming the brain for vulnerability to these disorders.


University Graduate
Postdoc : candidates
should have obtained a PhD degree in Molecular/Cellular Neurobiology,
Molecular Life Sciences or equivalent. Preferably, candidates have a
background in Developmental Biology, experience with animal models, and
a high affinity for fundamental research related to clinical problems.
Relevant experience with animal behavioural research is an advantage.
PhD student: candidates for the PhD position should have obtained a
Master’s degree in Molecular/Cellular Neurobiology, Molecular Life
Sciences or equivalent.


Radboud University Nijmegen Faculty of Science, Mathematics and Computing Science
Strategically located in Europe, Radboud
University Nijmegen is one of the leading academic communities in the
Netherlands. A place with a personal touch, where top-flight education
and research take place on a beautiful green campus in modern buildings
with state-of-art facilities.

The challenge of the research performed at the
Department of Molecular Animal Physiology is mapping the brain from
genotype to molecular pathways in neurodevelopmental trajectories to
neuronal circuitry phenotypes and, even further, to behaviour and
cognition. The department is part of the Donders Centre for
Neuroscience (theme 2: Functional Neurogenomics/Neurodevelopment, in
which the roles of [brain] genes and their products are examined, often
in [genetically modified] neuronal cells in culture and in [genetically
modified] animal models). The department is affiliated with and housed
in the Nijmegen Centre for Molecular Life Sciences (NCMLS; theme 3:
Cell growth and differentiation) of Radboud University. Website:
www.ru.nl/molanphys/. The Donders Centre for Neuroscience brings
together multidisciplinary basic and clinical research groups from the
Faculty of Science and the Radboud University Nijmegen Medical Centre.
The researchers at the Centre combine basic research on cognitive
neuroscience and applied clinical research. Website: www.ru.nl/dcn. The
Nijmegen Centre for Molecular Life Sciences (NCMLS) is a leading
European research school within the domain of Molecular Mechanisms of
Disease, provides an excellent and challenging research environment,
and includes departments of the Radboud University Nijmegen Medical
Centre. Multidisciplinary research within the NCMLS is also reflected
in international MSc and PhD programmes. Website: www.ncmls.eu.

Conditions of employment

Employment basis: Temporary for specified period
Duration of the contract: Postdoc: three years. PhD student : four years.
Maximum hours per week: 40

Additional conditions of employment:
Postdoc: The candidate will be appointed as postdoctoral researcher for
an initial period of one year. The candidate’s performance will be
evaluated after that year. If the evaluation is positive, the contract
will be extended by 2 years. PhD student : The candidate will be
appointed as a PhD student for a period of four years. The candidate’s
performance will be evaluated after 18 months. If the evaluation is
positive, the contract will be extended by 2.5 years.

Additional Information

Additional information about the vacancy can be obtained from:

prof. dr. G.J.M. Martens
Telephone number: +31(0)24- 3610564
E-mail address: g.martens@ncmls.ru.nl
Or additional information can be obtained through one of the following links.

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You can apply for this job before 01-10-2008 by sending your application to:

Faculteit der Natuurwetenschappen, Wiskunde en Informatica
RU Nijmegen, FNWI, P&O , mrs. M. Coppus
Postbus 9010, 6500 GL Nijmegen, NL

E-mail address: pz@science.ru.nl

When applying for this job always mention the vacancy number 62.30.08.
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