Germany-Phd: Ph.D.-Positions in Neuroscience (Technical University Munich)

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We are looking for 2 Ph.D. or M.D./ Ph.D. students, who want to join our new group at the Institute of Neuroscience at the Technical University of Munich (TUM). We offer two projects that use in vivo imaging in mice and zebrafish to study the mechanisms of axon remodeling:

Project 1 – Time-lapse studies of axon remodeling during development

During development, axons in the nervous system remodel extensively in order to adjust to the outside world. We have previously discovered novel mechanisms of peripheral axon remodeling and now plan to investigate the occurrence of similar mechanisms in the CNS. This project will particularly focus on a developmental role of glial cells.

Project 2 – In vivo imaging of motor axon degeneration in ALS models
 
Amyotrophic lateral sclerosis (ALS) is a devastating disease, in which motor neurons die. We aim to understand how neurons degenerate in animal models of ALS by visualizing changes in motor axons, their synapses and supporting glial cells. We will specifically focus on pathological changes in axonal transport.

Both projects involve cutting-edge microscopy (confocal and two-photon), histology, use of fluorescent reporters, work with model organisms and disease models (mice, zebrafish). Our laboratory is supported by a Sofja-Kovalevskaja Award of the Alexander-von-Humboldt Foundation. The Institute of Neuroscience is a leading imaging laboratory affiliated with TUM, one of the top three German universities. Our students are trained as part of the PhD program “Medical life science and technology”. Recent publications and further information can be found at www.misgeld-lab.me.tum.de.

Salary will be available for 3 years, starting autumn 2007. Applicants should hold a bachelors/ masters degree or a German ‘Diplom’ (German medical students can apply already during their studies). If you have questions, please contact Thomas Misgeld. Send your electronic application (CV and statement of interest) to thomas.misgeld@lrz.tum.de.

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